Histamine intolerance test

Only for Germany and Austria

• We would like to point out that these tests and the shipping processes are optimized for Germany and Austria and are prepaid.
• Samples must be delivered to the German laboratory within 4 days. This cannot be guaranteed for samples shipped from other countries!
• Orders from countries other than Germany and Austria are therefore at your own risk. In this case, we only accept the payment method "Prepayment (directly to us)", as customers cannot then cancel the purchase, e.g., because the sample arrived at the laboratory unusable through their own fault. Purchases made with any other payment methods that customers could unlawfully reverse will be immediately canceled and refunded.
• You can find more information about this from the manufacturer!

The amino acid histidine is one of the tissue hormones

In cases of suboptimal histamine breakdown, particularly where large amounts of histamine accumulate and there is insufficient activity of histamine-degrading enzymes such as diamine oxidase (DAO) and histamine N-methyltransferase (HNMT) in the liver, excessive amounts of histamine can build up in the body. Histamine intolerance (HIT) is therefore a sign of an imbalance between the production of histamine and its breakdown. It is not only foods with a high histamine content that influence the amount of histamine in the body: an excessive number of histamine-producing bacteria in the gut, allergies or medicines that inhibit histamine breakdown can also have an impact.

The symptoms typically associated with histaminosis can be varied. Excessive histamine levels can lead to circulatory problems, headaches, shortness of breath, allergy-like symptoms and skin rashes. However, gastrointestinal symptoms such as stomach pain, heartburn, cramps, bloating and diarrhoea are also possible. This urine test is used to measure histamine and its metabolites in the urine.

In the gut, histamine is primarily broken down by the enzyme diamine oxidase (DAO), producing imidazoleacetaldehyde and imidazoleacetic acid. As a second intracellular degradation pathway, histamine is converted by N-methyltransferase into the products N-methylhistamine, N-methylimidazoleacetaldehyde and N-methylimidazoleacetic acid. The relationships between N-methylhistamine and histamine, as well as between imidazoleacetic acid and histamine, provide insights into the function of DAO and the activity of HNMT.

The following parameters are investigated:

• Histamine
• Imidazoleacetic acid
• Imidazoleacetic acid/histamine ratio
• N-methylhistamine
• N-methylimidazoleacetic acid
• N-methylhistamine to histamine ratio Diagnosis

The test kit contains:

• 1 set of sample collection instructions
• 1 urine collection cup
• 1 yellow urine tube (Urine Monovette)
• 1 yellow tip
• 1 dispatch container for the Urine Monovette
• 1 dispatch envelope

How does the ordering process work?

Once you have placed your order, the test kit you have chosen will be sent to you along with detailed instructions. You place your sample in a sample tube, send it in the provided envelope to Mediveres’ partner laboratory, GANZIMMUN Diagnostics GmbH, and will receive your results, including an assessment of your profile, within 5–7 days.