Zonulin stool test

Only for Germany and Austria

• We would like to point out that these tests and the shipping processes are optimized for Germany and Austria and are prepaid.
• Samples must be delivered to the German laboratory within 4 days. This cannot be guaranteed for samples shipped from other countries!
• Orders from countries other than Germany and Austria are therefore at your own risk. In this case, we only accept the payment method "Prepayment (directly to us)", as customers cannot then cancel the purchase, e.g., because the sample arrived at the laboratory unusable through their own fault. Purchases made with any other payment methods that customers could unlawfully reverse will be immediately canceled and refunded.
• You can find more information about this from the manufacturer!

Zonulin is a marker of potentially increased permeability of the intestinal epithelial cells and may indicate the presence of disease

If the gut is colonised by an abnormal mix of microorganisms, the gut flora can only fulfil its physiological functions to a limited extent. The resulting disruption of the microbial barrier ultimately leads to pathological mechanisms that cause latent inflammatory changes in the mucosa and subsequent impairments in permeability. This makes it easier for pathogenic bacteria, viruses, fungi or parasites, in the context of microecological disturbances, to penetrate mucosal receptors more readily, multiply more rapidly and trigger infections.

Depending on the species of micro-organism, microbial metabolism ultimately produces either substrates that are beneficial to the intestinal environment or those that harm the system in various ways. A loosening of the ‘tight junctions’ in the intestinal epithelium leads to increased permeability of the mucosa, a condition known as leaky gut. This allows many molecules to pass from the gastrointestinal tract into the bloodstream and trigger various reactions.

Endotoxin is of particular significance. This molecule, also known as lipopolysaccharide (LPS), originates from the surface of Gram-negative bacteria and acts as an inflammatory marker. Chronic overloading of the blood with LPS can lead to what is known as ‘silent inflammation’. This persistent inflammatory state can contribute to further conditions such as metabolic syndrome, obesity, type 2 diabetes or atherosclerosis. The LPS concentration in the blood can be measured directly using laboratory diagnostic methods.

Zonulin, a protein, binds to specific receptors on the epithelial cells of the intestinal wall. This triggers a series of biochemical processes that lead to the opening of tight junctions and increased permeability of the intestinal epithelial cells. In patients with active coeliac disease, levels of zonulin and zonulin antibodies are elevated. Furthermore, many coeliac patients are affected by other autoimmune diseases, such as insulin-dependent diabetes, multiple sclerosis and rheumatoid arthritis. It is believed that elevated zonulin levels play a decisive role in this context.

The results form the basis for a personalised treatment plan, which should only be undertaken after consultation with a doctor or therapist.

The test kit includes:

• 1 sample collection guide
• 1 set of instructions for accessing results
• 1 sample accompanying form
• 1 guarantee certificate
• 1 sample container, including label, in a shipping container
• 1 stool collection bag
• 1 Postbag

How does the ordering process work?

Once you have placed your order, the test kit you have chosen will be sent to you along with detailed instructions. You place your sample in the sample container, send it in the provided envelope to Mediveres’ partner laboratory, GANZIMMUN Diagnostics GmbH, and will receive your results, including an assessment of your profile, within 5–7 days.